The NFL will showcase a rare neutral-site game on American soil Monday night when the Buffalo Bills and San Francisco 49ers meet at the home of the Arizona Cardinals, State Farm Stadium in Glendale, Ariz.
The game pits the AFC East-leading Bills (8-3) against the NFC West-trailing 49ers (5-6) about 700 miles from its originally scheduled venue -- Levi's Stadium in Santa Clara, Calif. -- due to new COVID-related restrictions in Santa Clara County.
In fact, the 49ers will spend the next three weeks practicing and playing away from home, with their Dec. 13 matchup against Washington also already rescheduled for Arizona before San Francisco travels to oppose the Dallas Cowboys on Dec. 20. The 49ers and Arizona Cardinals will meet at State Farm Stadium, as originally scheduled, on Dec. 26.
Playing at a neutral site is nothing new to the NFL, which has scheduled as many as five regular-season contests in Europe and Mexico in a single season. The last time the 49ers participated in a neutral-site game, it was at Wembley Stadium in London in 2013, a game they won 42-10 against the Jacksonville Jaguars.
The Bills, meanwhile, are one of the few teams that have experience playing in a third-party NFL stadium in recent years. That occurred in November 2014, when their home game against the New York Jets was moved to Detroit because of a state of emergency having been put in place in Buffalo due to a blizzard.
The Bills won that game 38-3.
Buffalo and San Francisco haven't gone head-to-head since 2016 and haven't met in a closely contested game since a 10-3 49ers road win in 2008.
The scores of the two meetings since have been 45-3 (49ers) and 45-16 (Bills), with the home team winning each.
The all-time series stands at 6-6.
Buffalo enters the contest having won four of five, with the lone loss, coincidentally, having come at Arizona in Week 10, a dramatic 32-30 defeat to the Cardinals.
After a bye the following week, the Bills resurfaced at home last week and beat the Los Angeles Chargers 27-17 behind a running and a passing touchdown from Josh Allen and a trick-play score on a 20-yard pass from Cole Beasley to fellow wideout Gabriel Davis.
The win was Buffalo's eighth in its first 11 games, the same mark the team had at this point a year ago. The goal this time around: avoid the 2-3 finish that kept the Bills out of the playoffs in 2019.
"I like where we are; I like the way we're improving through the course of the season," Bills coach Sean McDermott said. "I think there always is a gap between where we are and where we're trying to get to. We're always in pursuit of it. I think that's a healthy approach and that's really where we are with this year's team. Last year is in the past."
The 49ers have already lost twice as many games as last regular season, when they shared the top record in the NFC at 13-3. Last week's 23-20 road win over the Los Angeles Rams not only snapped a three-game losing streak but also got them one step closer to where they want to go -- back to the playoffs.
The 49ers returned wide receiver Deebo Samuel and running back Raheem Mostert from injuries against the Rams, and they are expected to be complemented by wide receiver Brandon Aiyuk this week now that his COVID-mandated absence has ended.
San Francisco coach Kyle Shanahan is looking forward to the reunion.
"Just getting all these guys back, it just brings some continuity to everyone," he said. "I know it's a lot easier for the quarterbacks, too."
The 49ers will take the field in search of their 50th win on a Monday in their history. No NFL franchise has reached 50, although the Pittsburgh Steelers also have a chance on Monday when they host the Washington Football Team.
--Field Level Media